D4 Dopamine Receptor Proteins

Protein Information

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

Synonyms

AW125663; D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; D4R; D4RA; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; dopamine receptor D4; Drd4; Drd-4; seven transmembrane helix receptor